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Contact information:

Phone: +34 871 205000  ext. 64547

@ssib.es

Since 2005, I have developed a sustained research career as a specialist in big data analysis and multi-omic project design in biomedicine and immunology in various national and international research centers. My earliest studies were focused on regenerative medicine and embryonic stem cells, participating as a visiting researcher in the laboratory of Dr. José B. Cibelli at the Michigan State University, where I stayed for four years. At the end of this period, I returned to Spain to finish my Ph.D. at the University of Oviedo. In this final phase of my doctoral period, I focused on studying how epigenetic mechanisms regulate the dedifferentiation processes of tumor cells, work that culminated in the presentation of my doctoral thesis, directed by Dr. Mario Fraga in The University Institute of Oncology of Asturias (IUOPA).
After completing my Ph.D. in 2015, I started my postdoctoral training in the Department of Immunology of the University Hospital of Asturias under the supervision of Carlos Lopez-Larrea, a pioneer in the study of histocompatibility and autoimmunity with over 200 indexed scientific articles published. In 2017, I was awarded a Juan de la Cierva-Formación grant to study the epigenetic mechanisms associated with immunity and, in 2019, I obtained a Juan de la Cierva-Incoporación grant. Since then, I have established an independent line of research to study how the epigenomic networks contribute to the cellular differentiation processes associated with immune response and how these molecular mechanisms can be exploited as therapeutic targets for the treatment of autoimmune diseases and cancer. I supervised one undergraduate degree project and one master's degree project during this period. In addition, I have been a member of the Network of Kidney Diseases (REDINREN) of The Carlos III Health Institute (ISCIII), of the Spanish Immunology society since 2015, and of the bank of collaborating experts of The State Research Agency (Agencia Estatal de Investigación, AEI) since 2021. Finally, I have obtained several technical accreditations, including the Laboratory animal science for researchers level B (ICSCYL) and Flow cytometry operator (Becton Dickinson).

Selected list of publications

  • Ramon M. Rodriguez, María Laura Saiz, Beatriz Suarez-Álvarez, Carlos López-Larrea.  Epigenetic networks driving T cell identity and plasticity during immunosenescence. Trends in Genetics. 2022 Feb;38(2):120-123. doi: 10.1016/j.tig.2021.08.014.

  • Ramon M. Rodriguez, María P Hernández-Fuentes, Viviana Corte-Iglesias, et al. Defining a Methylation Signature Associated With Operational Tolerance in Kidney Transplant Recipients. Frontiers in Immunology. 2021 Aug 20;12:709164. doi: 10.3389/fimmu.2021.709164.

  • Aroa Baragaño Raneros, Ramon M Rodriguez, Aida Bernardo Flórez, et al. Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia. Oncoimmunology. 2021 Mar 25;10(1):1897294. doi: 10.1080/2162402X.2021.1897294.

  • Paula Díaz-Bulnes, María Laura Saiz, Carlos López-Larrea, Ramón M.  Rodríguez. Crosstalk Between Hypoxia and ER Stress Response: A Key Regulator of Macrophage Polarization. Frontiers in Immunology. 2020 Jan 8;10:2951. doi: 10.3389/fimmu.2019.02951.

  • Ramon M Rodriguez, Beatriz Suarez-Alvarez, Jose L Lavín, et al. Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes. Cell Reports. 2019 Oct 22;29(4):860-872.e5. doi: 10.1016/j.celrep.2019.09.035.

  • Ramon M Rodriguez, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea. Therapeutic Epigenetic Reprogramming of Trained Immunity in Myeloid Cells. Trends in Immunology. 2019 Jan;40(1):66-80. doi: 10.1016/j.it.2018.11.006.

  • Beatriz Suarez‐Álvarez, Ramón M Rodríguez, Karin Schlangen, et al. Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole‐genome DNA methylation pattern. Aging Cell. 2017 Apr;16(2):293-303. doi: 10.1111/acel.12552.

  • Ramon M Rodriguez, Beatriz Suarez-Alvarez, José L Lavín, et al. Epigenetic Networks Regulate the Transcriptional Program in Memory and Terminally Differentiated CD8+ T Cells. Journal of Immunology. 2017 Jan 15;198(2):937-949. doi: 10.4049/jimmunol.1601102.

  • Ramon M Rodriguez, Beatriz Suarez-Alvarez, David Mosén-Ansorena, et al. Regulation of the transcriptional program by DNA methylation during human αβ T-cell development. Nucleic Acids Research. 2015 Jan;43(2):760-74. doi: 10.1093/nar/gku1340.

  • Ramon M Rodriguez, Beatriz Suarez-Alvarez, Ruben Salvanés. Role of BRD4 in hematopoietic differentiation of embryonic stem cells. Epigenetics. 2014 Apr;9(4):566-78. doi: 10.4161/epi.27711.

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